JAMA, 325(14), pp.14031413
Costly GLP-1 Drugs are Rarely Covered for Weight Loss by Marketplace Plans
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Formulation: Tirzepatide 10 mg/mL + Levocarnitine 100 mg/mL Schedule: Weeks 1 to 4: 2.5 mg tirzepatide (25 units) once weekly, delivering 25 mg levocarnitine Weeks 5 to 8: 5 mg tirzepatide (50 units) once weekly, delivering 50 mg levocarnitine Weeks 9 to 12: 7.5 mg tirzepatide (75 units) once weekly, delivering 75 mg levocarnitine Weeks 13+: 10 mg tirzepatide (100 units) once weekly, delivering 100 mg levocarnitine, with potential titration to 12.5 mg or 15 mg based on response and tolerability Supporting measures: Protein intake: 0.7 to 1.0 g per pound of body weight daily Resistance training: 3 to 4 sessions per week minimum Hydration: minimum 64 oz water daily Monitor body composition (not just scale weight) monthly Protocol 2: Enhanced fat oxidation for active researchers Goal: Maximize fatty acid oxidation capacity during concurrent exercise programs

BofA also flagged that Lillys obesity pipeline including retatrutide and eloralintide could extend revenue growth beyond 2036, when Mounjaros patent protection begins to expire